This year’s Bits&Chips System Architecting Conference will be organized as an online event series again. Through an inspiring program, this event always brings together system architects to share successful and failed development cases in both high tech and civil engineering.

Shortly, we will announce the next webinar of the System Architecting Conference 2024.
In the meantime you can watch the videos of previous webinars via the button on top.


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Webinar video 2023

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28 March 2023 – Johannes Jobst (Demcon)
Systems engineering for SMART: accelerator-based, high-volume production of medical isotopes.

Webinar videos 2021 & 2022

In 2021 and 2022, the Bits&Chips System Architecting Conference was also organized as an online event series.

Take a look at the program of 2021 here. If you want to have access to our video archive, please contact for the possibilities. 


System architecture (and systems engineering) are distinguishing disciplines in the development and commercialization of complex systems, products and machines. The system architect’s decisions can make or break a product. A system architect needs to be a good communicator and problem solver, because he or she is in charge of the development of a system architecture. However, the system architect should also have technical knowledge from different kinds of disciplines.

Experience is an important factor, but the system architect can also learn a lot from his peers. Exchanging lessons learned from successful and failed development cases is invaluable to sharpen his mind. 

Target audience

The target audience consists of all involved in the development and commercialization of complex products and machines:

  • System architects
  • System engineers
  • Technical management
  • Decision makers of complex-system companies
  • Product managers

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Johannes Jobst (Demcon)

Systems engineering for SMART: accelerator-based, high-volume production of medical isotopes

6 April 2023, 15:30 – 16:15 hours, GMT+2

In this presentation Johannes Jobst will present an alternative factory design where Molybdenum-99 (Mo-99) isotopes are produced from stable Mo-100 by high-intensity electron irradiation (75 MeV, 40 mA → 3 MW heat load). This SMART factory was under development by the Institute of Radio Elements (IRE) in Fleurus, Belgium.

The current way of producing Molybdenum-99, one of the key medical isotopes worldwide with tens of millions of diagnoses per year, does not have a long-term perspective. The used fission of U-235 in nuclear reactors is not sustainable due to reactor age, the high-level radioactive waste generated and proliferation concerns.
The fact that industrial-scale production of Mo-isotopes is achievable by high-intensity electron irradiation was realized by ASML as a byproduct of evaluating free electron lasers as a potential EUV source. While this project, which received National Icon status in 2016, was too far from the core business of the Veldhoven builder of lithography machines, ASML helped develop the concept further with a number of partners under the leadership of IRE.
In this alternative SMART factory design, a Mo-100 target is subject to high heat loads and material degradation due to radiation damage from the high-intensity electron beam that converts Mo-100 to the Mo-99 product. To manage those extreme conditions, the target is cooled with a high flow of liquid sodium. Further, an intense shower of unwanted, high-energy photons and neutrons is released in the process. Those need to be shielded to protect the environment, personnel as well as electronic equipment.

Johannes will discuss the system engineering challenges that are crucial for such a large project with tight timeline, big teams at different project partners and intrinsic, fundamental uncertainties.

Johannes Jobst Demcon

Johannes is working as system engineer at Demcon where he is developing high-tech products for a variety of customers. He has a background in physics, which he studied in Berlin and Erlangen (Germany) and performed (PhD) research in Erlangen (Germany), Leiden (Netherlands) and Columbia University (New York). His expertise is on fundamental research of quantum transport and device physics in two-dimensional materials, material characterization, electron microscopy development and tooling for the semiconductor industry.
As one of two system architects, he was responsible for the design and engineering of the exposure system of IRE’s SMART factory with a team of ~80 engineers at Demcon.